Regulation of Stress Responses and Translational Control by Coronavirus

Regulation of Stress Responses and Translational Control by Coronavirus

To Sing Fung, Ying Liao, Ding Xiang Liu

Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.

2016

coronavirus, ER stress, Unfolded Protein Response, p38, JNK, eIF2α, PKR, p-ERK, GADD34/PP1, nsp1, translational control

DOI: 10.3390/v8070184

Viruses

MDPI AG

Microbiology

EN