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                <text>Dominio científico: Coronavirus</text>
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              <text>Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence</text>
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              <text>Celestino Sardu, Jessica Gambardella, Marco  Bruno Morelli, Xujun Wang, Raffaele Marfella, Gaetano Santulli</text>
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              <text>The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.</text>
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              <text>coronavirus, covid, ACE2, acute kidney injury, cytokine storm, Blood pressure, catepsin</text>
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              <text>Epidemiology and Health</text>
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              <text>Korean Society of Epidemiology</text>
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              <text>Medicine</text>
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