https://www.socictopen.socict.org/files/original/4d55cfbd1665b4e748914d3e4e50f7a9.pdf cf00aec5f93d78b45bbc10d87dfab545 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Morphological and immunohistochemical characteristics of changes in the bronchopulmonary lymph nodes in patients with a new COVID-19 coronavirus infection (based on autopsy results) Creator An entity primarily responsible for making the resource D. N. Fedorov, P. A. Korosteleva, D. I. Zybin, M. A. Popov, V. M. Tyurina, A. V. Varlamov Description An account of the resource Background: Research into the pathogenesis and morphogenesis of new coronavirus infection (COVID-19) is currently a hot topic that requires the accumulation, management and analysis of the data. Understanding the mechanisms of the disease and their characteristics would help to improve diagnostic quality, treatment efficacy and reduce mortality. Aim: To identify morphological and immunohistochemical characteristics of the bronchopulmonary lymph node tissues in autopsied patients with COVID-19. Materials and methods: The study was carried out on 44 autopsy samples from patients who were hospitalized and died from the new coronavirus infection COVID-19 in the Moscow Regional Research and Clinical Institute. Macroscopic, histological, and immunohistochemical assessment methods were used.Results: We found stereotypical abnormalities in the morphology and cellular composition of the lymphoid tissue depending on the duration of the disease. These included signs of B-cell-mediated immunity suppression manifested by a decrease in the number and size of lymphoid follicles and occurs at latest after 7 days from the onset of the disease. In the patients with the disease duration of up to 14 days, the T-cell pool of the lymph nodes is represented mainly by CD4+ T-lymphocytes. With longer duration of the disease, there is a gradual increase in the number of lymphoid follicles and their sizes, with changes of the CD4+ to CD8+ T-cell ratio towards higher CD8+ counts. After 21 days of the disease, the CD4+ to CD8+ ratio levels off.Conclusion: The results obtained indicate a direct damaging effect of SARS-CoV-2 on the lymph node tissues of the bronchopulmonary group. The possibility of secondary transient immune deficiency and infectious  complications in patients with a new coronavirus infection is discussed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource pathogenesis, covid-19 infection, lymphoid tissue, pathological anatomy Identifier An unambiguous reference to the resource within a given context 10.18786/2072-0505-2020-48-034 Source A related resource from which the described resource is derived Alʹmanah Kliničeskoj Mediciny Publisher An entity responsible for making the resource available MONIKI Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine