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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Diagnostic Methods for Feline Coronavirus: A Review</text>
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              <text>Saeed Sharif, Siti Suri Arshad, Mohd Hair-Bejo, Abdul Rahman Omar, Nazariah Allaudin Zeenathul, Amer Alazawy</text>
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              <text>Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective vaccine, nor a curative treatment for FIP, a diagnostic protocol for FCoV would greatly assist in the management and control of the virus. Clinical findings in FIP are non-specific and not helpful in making a differential diagnosis. Haematological and biochemical abnormalities in FIP cases are also non-specific. The currently available serological tests have low specificity and sensitivity for detection of active infection and cross-react with FCoV strains of low pathogenicity, the feline enteric coronaviruses (FECV). Reverse transcriptase polymerase chain reaction (RT-PCR) has been used to detect FCoV and is rapid and sensitive, but results must be interpreted in the context of clinical findings. At present, a definitive diagnosis of FIP can be established only by histopathological examination of biopsies. This paper describes and compares diagnostic methods for FCoVs and includes a brief account of the virus biology, epidemiology, and pathogenesis.</text>
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              <text>2010</text>
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              <text>DOI: 10.4061/2010/809480</text>
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          <name>Source</name>
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              <text>Veterinary Medicine International</text>
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              <text>Hindawi Limited</text>
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          <name>Coverage</name>
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              <text>Veterinary medicine</text>
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          <name>Language</name>
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              <text>EN</text>
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