In silico study of dynamic level interaction between CLF36 peptide and coronavirus surface protein in Bovine coronaviruses

In silico study of dynamic level interaction between CLF36 peptide and coronavirus surface protein in Bovine coronaviruses

Mojtaba Tahmoorespur, Abdulaziz Hamadalahmad, Marjan Azghandi, Zana Pirkhezranian

Considering the fact that coronavirus is one of the major causes of calf diarrhea syndrome, this study aimed to investigate the interaction between the peptide cLF36 and the coronavirus protein by utilizing computational methods. Coronavirus amino acid sequence was obtained and molecular docking between coronavirus and the engineered camel lactoferrin was performed. The simulation model was conducted using PROMX model. The results showed that the highest bond length was 2.5 Å and the lowest 1.7Å which makes the connection between the two proteins strong, robust, and close to reality. According to the obtained results, cLF36 is a promising potential drug in the treatment of calf diarrhea.

2020

coronavirus, calf diarrhea, Molecular Docking Simulation, camel lactoferrin

10.30493/dls.2020.235579

Dysona. Life Science

E-NAMTILA

Science, Biology (General)