Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Susanna K.P. Lau, Antonio C.P. Wong, Hayes K.H. Luk, Kenneth S.M. Li, Joshua Fung, Zirong He, Flora K.K. Cheng, Tony T.Y. Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C.K. Lau, Kitty S.C. Fung, Patrick C.Y. Woo

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.

2020

SARS, severe acute respiratory syndrome, Viruses, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, coronavirus disease

10.3201/eid2612.202308

Emerging Infectious Diseases

Centers for Disease Control and Prevention

Medicine, Infectious and parasitic diseases