https://www.socictopen.socict.org/files/original/fa19058c154649115018c994a2aa9b39.pdf 53fd19ca4068d1f1910a6b9ff1556abf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS Virus Papain-Like Protease: A Mysterious Weapon Creator An entity primarily responsible for making the resource Reza Nejat, Ahmad Shahir Sadr Description An account of the resource Introduction: Papain-like protease (PLpro) of SARS-CoV in association with 3Chemotrypsin-like protease (3CLpro or Mpro) are two proteases which auto-proteolyze replicase polyproteins pp1a/pp1ab. These poly-proteins are translated from ORF1a/ORF1b of the virus genome. Cleavage of pp1a/pp1ab releases non-structural proteins of the virus which orchestrate viral replication. In addition, PLpro as a deubiquitinase and deISGylase modifies the proteins involved in recognition of the virus by the sensors of host cell innate immunity system. In this manner, the virus reforms the ubiquitination and ISGylation of the cell proteins to progress its own replication without any interference from host cell restrictive strategies against the viruses. Furthermore, PLpro blocks IRF3 activation independent of deubiquinating processes. Besides, PLpro induces pulmonary fibrosis through pathways involving ROS and MAPK. Conclusion: Inhibition of PLpro allows innate immunity to sense and react against the invasion of SARS-CoV and to activate IRF3 to induce type I IFN expression. Thenceforth, proper development and signaling of innate immunity result in a long-term efficient cell/humoral adaptive immunity. Moreover, suppression of PLpro prevents cleavage of nsp3 and hence replication of the virus and through abolishing ubiquitin-proteasome/MAPK/ERK- and ROS/MAPK-mediated pathways prevent pulmonary fibrosis. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource SARS-coronavirus, papain-like protease, ubiquitination, interferon-stimulated gene, Deubiquitination, 15 (ISG15) Identifier An unambiguous reference to the resource within a given context 10.18502/jbe.v5i4.3873 Source A related resource from which the described resource is derived Journal of Biostatistics and Epidemiology Publisher An entity responsible for making the resource available Tehran University of Medical Sciences Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Probabilities. Mathematical statistics