https://www.socictopen.socict.org/files/original/8f73ec5dbe3e2da16fc3ab8a7c681c6c.pdf 62a18702f9c2210cf0bec090eb7c1601 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models. Creator An entity primarily responsible for making the resource Rafal Butowt, Nicolas Meunier, Bertrand Bryche, Christopher S von Bartheld Description An account of the resource One of the most frequent symptoms of COVID-19 is the loss of smell and taste. Based on the lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally assumed that the new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) does not infect olfactory neurons. Recent studies have reported otherwise, opening the possibility that the virus can directly infect the brain by traveling along the olfactory nerve. Multiple animal models have been employed to assess mechanisms and routes of brain infection of SARS-CoV-2, often with conflicting results. We here review the current evidence for an olfactory route to brain infection and conclude that the case for infection of olfactory neurons is weak, based on animal and human studies. Consistent brain infection after SARS-CoV-2 inoculation in mouse models is only seen when the virus entry proteins are expressed abnormally, and the timeline and progression of rare neuro-invasion in these and in other animal models points to alternative routes to the brain, other than along the olfactory projections. COVID-19 patients can be assured that loss of smell does not necessarily mean that the SARS-CoV-2 virus has gained access to and has infected their brains. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource virus, covid-19, SARS-CoV-2, neuroinvasion, Brain infection, Olfactory system Identifier An unambiguous reference to the resource within a given context 10.1007/s00401-021-02314-2 Source A related resource from which the described resource is derived Acta neuropathologica