https://www.socictopen.socict.org/files/original/06a12525fff220069c4807f765420de7.pdf 34c547950bcfb28adbf7a7630cfd773a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hypercytokinemia and Pathogen–Host Interaction in COVID-19 Creator An entity primarily responsible for making the resource Badawi A Description An account of the resource Alaa Badawi1,2 1Public Health Risk Sciences Division, Public Health Agency of Canada, Toronto, ON, Canada; 2Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCorrespondence: Alaa BadawiPublic Health Risk Sciences Division, Public Health Agency of Canada, 180 Queen Street West, Toronto, ON M5V 3L7, CanadaEmail alaa.badawi@canada.caAbstract: Severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) is a novel coronavirus identified as the cause of coronavirus disease-2019 (COVID-19) that began in Wuhan, China in late 2019 and spread now in 210 countries and territories around the world. Many people are asymptomatic or with mild symptoms. However, in some cases (usually the elderly and those with comorbidities) the disease may progress to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction that can lead to death. Such wide interindividual differences in response to SARS-CoV-2 infection may relate to several pathogen- and host-related factors. These include the different levels of the ubiquitously present human angiotensin I converting enzyme 2 (ACE2) receptors gene expression and its variant alleles, the different binding affinities of ACE2 to the virus spike (S) protein given its L- and S-subtypes and the subsequent extent of innate immunity-related hypercytokinemia. The extensive synthesis of cytokines and chemokines in coronavirus diseases was suggested as a major factor in exacerbating lung damage and other fatal complications. The polymorphisms in genes coding for pro-inflammatory cytokines and chemokines have been associated with mediating the response and susceptibility to a wide range of infections and their severe outcomes. Understanding the nature of pathogen–host interaction in COVID-19 symptomatology together with the role of hypercytokinemia in disease severity may permit developing new avenues of approach for prevention and treatment and can delineate public health measures to control the spread of the disease.Keywords: SARS-CoV, MERS-CoV, SARS-CoV-2, COVID-19, hypercytokinemia Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource MERS-CoV, SARS-CoV, covid-19, Pandemic, SARS-CoV-2 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pathology