Application of Antiviral Polyoxometalates to Living Environments—Antiviral Moist Hand Towels and Stationery Items

Application of Antiviral Polyoxometalates to Living Environments—Antiviral Moist Hand Towels and Stationery Items

Katsuaki Dan, Katsuyuki Fujinami, Hajime Sumitomo, Yasuaki Ogiwara, Shigehiko Suhara, Yoshiharu Konno, Mitsuhiro Sawada, Yusuke Soga, Atsushi Takada, Keita Takanashi, Kenji Watanabe, Tatsuo Shinozuka

Safe, secure, and environmentally friendly active substances should be developed. VB (virus block) refers to an antibacterial/antiviral mixture of two kinds of polyoxometalates (PMs), i.e., K11H[(VO)3(SbW9O33)2]·27H2O (VB2) and α-Na2[SbW9O33]9− (VB3), and polyhexamethylene biguanide (PHMB). VB was demonstrated to exert antiviral effects on cultured cells. The effects were maintained even in hygiene products or solids. The antiviral effects were analyzed by reverse transcription–polymerase chain reaction (RT–PCR), and the results were correlated with TCID50, potentially eliminating the need for handling infectious viruses. VB was demonstrated to be extremely effective (up to 99.99% inhibition) in cultured cells, with antibacterial/antiviral effects maintained in VB-containing hygiene products. VB was applied to solids, demonstrating their high applicability and versatility. VB withstands high temperatures regardless of materials because its effects are enhanced by more frequent contact with viruses and bacteria due to the increased surface area of the compound.

2020

Influenza Virus, SARS-CoV-2, MRSA, Norovirus, polyoxometalate, <i>Bacillus cereus</i>

10.3390/app10228246

Epidemiology and Health

Korean Society of Epidemiology

Biology (General), Chemistry, Engineering (General). Civil engineering (General), Technology, Physics