Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report

Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report

Novella Carannante, Novella Carannante, Giuseppe Fiorentino, Giuseppe Fiorentino, Antonio Corcione, Antonio Corcione, Raffaele Di Sarno, Raffaele Di Sarno, Micaela Spatarella, Micaela Spatarella, Nicola Maturo, Nicola Maturo, Fiorentino Fragranza, Fiorentino Fragranza, Pierpaolo Di Micco, Pierpaolo Di Micco

Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. No drug has demonstrated therapeutic efficacy for COVID-19. Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19.

2020

covid-19, pneumonia, SARS-CoV-2, Case report, Immunoglobulin, Pentaglobin

10.3389/fmed.2020.00388

Epidemiology and Health

Korean Society of Epidemiology

Medicine (General)