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                <text>Coronavirus</text>
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                <text>Dominio científico: Coronavirus</text>
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              <text>Respiratory Animal Models in the Common Marmoset (Callithrix jacchus)</text>
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              <text>Christoph Curths, Sascha Knauf, Franz-Josef Kaup</text>
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              <text>Common marmosets (Callithrix jacchus) are small non-human primates (NHPs) that are often used for respiratory research. Translational animal models of various pulmonary diseases in marmosets have been developed in favor of models in old world monkeys (OWM, e.g., rhesus or cynomolgus monkeys). The marmoset has the size of a rat (350–450 g), is easier to handle, and the husbandry, care, and management of colonies is much easier compared to OWMs. In contrast to rodents, marmosets provide a high homology to humans, which become especially visible in lung architecture and branching pattern. Features of inflammatory (e.g., COPD) pulmonary diseases can be modeled in marmosets as well the species is used to study bacterial and viral infection. Models for human melioidosis, tuberculosis, anthrax, as well as infections with SARS-associated coronavirus (SARS-CoV), influenza A virus and adenovirus are already established. Toxicological studies often use marmoset monkeys for the advantage of immunological identical twins that are produced by a Callitrichinae-specific placentation type, which ultimately causes blood chimerism. Relatively new approaches in gene therapy use marmosets for respiratory disease research. In this review we will give an overview of existing respiratory marmoset models and their impact on biomedical research.</text>
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              <text>2014</text>
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              <text>Animal Models, respiratory diseases, nonhuman primate, marmoset</text>
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              <text>10.3390/vetsci1010063</text>
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              <text>Epidemiology and Health</text>
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          <name>Publisher</name>
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              <text>Korean Society of Epidemiology</text>
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          <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <text>Veterinary medicine</text>
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