Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
Título
Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
Autor
Flavia Chiuppesi, Marcela d’Alincourt Salazar, Heidi Contreras, Vu H. Nguyen, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Mindy Kha, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Roman Levytskyy, Nancy D. Ebelt, Tae Hyuk Kang, Xiwei Wu, Thomas F. Rogers, Edwin R. Manuel, Yuriy Shostak, Don J. Diamond, Felix Wussow
Descripción
Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.
Fecha
2020
Identificador
10.1038/s41467-020-19819-1
Fuente
Epidemiology and Health
Editor
Korean Society of Epidemiology
Cobertura
Science
Archivos
Colección
Citación
Flavia Chiuppesi, Marcela d’Alincourt Salazar, Heidi Contreras, Vu H. Nguyen, Joy Martinez, Yoonsuh Park, Jenny Nguyen, Mindy Kha, Angelina Iniguez, Qiao Zhou, Teodora Kaltcheva, Roman Levytskyy, Nancy D. Ebelt, Tae Hyuk Kang, Xiwei Wu, Thomas F. Rogers, Edwin R. Manuel, Yuriy Shostak, Don J. Diamond, Felix Wussow, “Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform,” SOCICT Open, consulta 18 de abril de 2026, https://www.socictopen.socict.org/items/show/8257.
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