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                <text>Dominio científico: Coronavirus</text>
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              <text>Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance.</text>
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              <text>Carleen Klumpp-Thomas, Heather Kalish, Jennifer Hicks, Jennifer Mehalko, Matthew Drew, Matthew J Memoli, Matthew D Hall, Dominic Esposito, Kaitlyn Sadtler</text>
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              <text>Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.</text>
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              <text>2021</text>
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              <text>coronavirus, spike protein, covid-19, Pandemic, SARS-CoV-2, D614G</text>
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              <text>10.1093/infdis/jiaa743</text>
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              <text>The Journal of infectious diseases</text>
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