Seroconversion to HCoV-NL63 in Rhesus Macaques

Seroconversion to HCoV-NL63 in Rhesus Macaques

Lia van der Hoek, Ernst J. Verschoor, Maarten F Jebbink, Martin Deijs, H. Lie Mulder, Ilse Kraaijvanger, Lynne Rumping, Ronald Dijkman

HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.

2009

HCoV-NL63, Rhesus macaques

DOI: 10.3390/v1030647

Viruses

MDPI AG

Microbiology

EN