https://www.socictopen.socict.org/files/original/9af0158a958b44b11d5f2ddb8c02cc1d.pdf 7674747b6f66f9a1f3c2faf112b06453 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck. Creator An entity primarily responsible for making the resource Katarina M Braun, Gage K Moreno, Peter J Halfmann, Emma B Hodcroft, David A Baker, Emma C Boehm, Andrea M Weiler, Amelia K Haj, Masato Hatta, Shiho Chiba, Tadashi Maemura, Yoshihiro Kawaoka, Katia Koelle, David H O'Connor, Thomas C Friedrich Description An account of the resource The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts and, potentially, escape human immunity depend on the ways genetic variation is generated and selected within and between individual hosts. Using domestic cats as a model, we show that SARS-CoV-2 consensus sequences remain largely unchanged over time within hosts, but dynamic sub-consensus diversity reveals processes of genetic drift and weak purifying selection. Transmission bottlenecks in this system appear narrow, with new infections being founded by fewer than ten viruses. We identify a notable variant at amino acid position 655 in Spike (H655Y) which arises rapidly in index cats and becomes fixed following transmission in two of three pairs, suggesting this site may be under positive selection in feline hosts. We speculate that narrow transmission bottlenecks and the lack of pervasive positive selection combine to constrain the pace of ongoing SARS-CoV-2 adaptive evolution in mammalian hosts. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1101/2020.11.16.384917 Source A related resource from which the described resource is derived bioRxiv : the preprint server for biology