https://www.socictopen.socict.org/files/original/a23a8d453363340e809309f890299455.pdf e74391f0d17a469b6ca533dc1b57a24e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Genomic Evolution and Variation of SARS-CoV-2 in the Early Phase of COVID-19 Pandemic in Guangdong Province, China. Creator An entity primarily responsible for making the resource Bai-Sheng Li, Zhen-Cui Li, Yao Hu, Li-Jun Liang, Li-Rong Zou, Qian-Fang Guo, Zhong-Hua Zheng, Jian-Xiang Yu, Tie Song, Jie Wu Description An account of the resource Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) with unknown origin spread rapidly to 222 countries, areas or territories. To investigate the genomic evolution and variation in the early phase of COVID-19 pandemic in Guangdong, 60 specimens of SARS-CoV-2 were used to perform whole genome sequencing, and genomics, amino acid variation and Spike protein structure modeling analyses. Phylogenetic analysis suggested that the early variation in the SARS-CoV-2 genome was still intra-species, with no evolution to other coronaviruses. There were one to seven nucleotide variations (SNVs) in each genome and all SNVs were distributed in various fragments of the genome. The Spike protein bound with human receptor, an amino acid salt bridge and a potential furin cleavage site were found in the SARS-CoV-2 using molecular modeling. Our study clarified the characteristics of SARS-CoV-2 genomic evolution, variation and Spike protein structure in the early phase of local cases in Guangdong, which provided reference for generating prevention and control strategies and tracing the source of new outbreaks. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource spike protein, severe acute respiratory syndrome coronavirus 2 (sars-cov-2), genomic evolution Identifier An unambiguous reference to the resource within a given context 10.1007/s11596-021-2340-3 Source A related resource from which the described resource is derived Current medical science