https://www.socictopen.socict.org/files/original/ea23241166a081ccc9bff720b9897521.pdf 1cc936d1e991b3ad4d5e29bc7a9ca82c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations. Creator An entity primarily responsible for making the resource Lajos Szente, István Puskás, Tamás Sohajda, Erzsébet Varga, Panna Vass, Zsombor Kristóf Nagy, Attila Farkas, Bianka Várnai, Szabolcs Béni, Eszter Hazai Description An account of the resource Veklury™ by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing excipient, sulfobutylether-beta-cyclodextrin (SBECD) that results in significant solubility enhancement. Complete amorphousness of the cyclodextrin-enabled REM formulation was demonstrated by X-ray diffraction, thermal analysis, Raman chemical mapping and electron microscopy/energy dispersive spectroscopy. The use of solubilizing carbohydrate resulted in a 300-fold improvement of the aqueous solubility of REM, and enhanced dissolution rate of the drug enabling the preparation of stable infusion solutions for therapy. 2D ROESY NMR spectroscopy provided information on the nature of REM-excipient interaction and indicated the presence of inclusion phenomenon and the electrostatic attraction between anionic SBECD and nitrogen-containing REM in aqueous solution. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Remdesivir, X-ray diffraction, inclusion, electrostatic interaction, 2D ROESY NMR, Differential scanning calorimetry, RAMAN-mapping, Solubilization, Sulfobutylether-beta-cyclodextrin Identifier An unambiguous reference to the resource within a given context 10.1016/j.carbpol.2021.118011 Source A related resource from which the described resource is derived Carbohydrate polymers