https://www.socictopen.socict.org/files/original/c3db8c50e7f6d97c2f8e31075ef9f023.pdf e74a95caff8e4b1f8b76653398d2b0ea Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose. Creator An entity primarily responsible for making the resource Mala K Maini, Catherine J Reynolds, Joseph M Gibbons, Corinna Pade, David K Butler, Teresa Cutino-Moguel, Marianna Fontana, Angelique Smit, Amanda Semper, Benjamin Chain, Tim Brooks, Charlotte Manisty, Thomas Treibel, James C Moon, Mahdad Noursadeghi, Daniel M Altmann, Áine McKnight, Rosemary J Boyton, Ashley D Otter, Katia Menacho, Jane E Sackville-West, Ana M Valdes Description An account of the resource SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1126/science.abh1282 Source A related resource from which the described resource is derived Science (New York, N.Y.)