https://www.socictopen.socict.org/files/original/8dd5ff04f6ce92d7fc508c97d3206075.pdf e2ea6b6de2726e10b8bf9e7f91d7327b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant Creator An entity primarily responsible for making the resource Filipe S. Fernando, Cintia H. Okino, Ketherson R. Silva, Camila C. Fernandes, Mariana C.M. Gonçalves, Maria F. S. Montassier, Rosemeri O. Vasconcelos, Hélio J. Montassier Description An account of the resource A Brazilian field isolate (IBV/Brazil/PR05) of avian infectious bronchitis virus (IBV), associated with development of nephritis in chickens, was previously genotyped as IBV variant after S1 gene sequencing. The aim of this study was to evaluate the levels of IL-6 in kidneys and trachea of birds vaccinated and challenged with IBV/Brazil/PR05 strain, correlating these results with scores of microscopic lesions, specific IBV antigen detection and viral load. The up-regulation of IL-6 and the increased levels of viral load on renal and tracheal samples were significantly correlated with scores of microscopic lesions. Reduced levels of viral load were detected in kidneys of birds previously vaccinated and challenged, compared to non-vaccinated challenged group, although markedly microscopic lesions were observed for both groups. The expression of IL-6, present both in the kidney and in the tracheas, was dependent on the load of the virus present in the tissue, and the development of lesions was related with IL-6 present in the tissues. These data suggest that variant IBV/Brazil/PR05 can induce the expression of proinflammatory cytokines in a manner correlated with viral load and increased IL-6 is involved in the tissue with the influx of inflammatory cells and subsequent nephritis. This may contribute with a model to the development of immunosuppressive agents of IL-6 to prevent acute inflammatory processes against infection with IBV and perhaps other coronaviruses, as well as contribute to the understanding of the immunopathogenesis of IBV nephropatogenic strains. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource interleucina-6, nefrite, vírus da bronquite infecciosa, IBV, variante, Galinhas Identifier An unambiguous reference to the resource within a given context DOI: 10.1590/S0100-736X2015000300002 Source A related resource from which the described resource is derived Pesquisa Veterinária Brasileira Publisher An entity responsible for making the resource available Colégio Brasileiro de Patologia Animal (CBPA) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN, PT