197 10 20655 https://www.socictopen.socict.org/files/original/715f49916fb96f82748e926bad06eba7.pdf 170d730228cf3ad005da33b09561e600 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Anti-Xa monitoring improves low-molecular-weight heparin effectiveness in patients with SARS-CoV-2 infection. Creator An entity primarily responsible for making the resource Mattia Trunfio, Elena Salvador, Daniela Cabodi, Letizia Marinaro, Chiara Alcantarini, Alberto Gaviraghi, Alice Trentalange, Filippo Lipani, Savino Sciascia, Dario Roccatello, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, Clinical Outcome, Activated factor X, Heparin, low molecular weight heparin, and related compounds Identifier An unambiguous reference to the resource within a given context 10.1016/j.thromres.2020.09.039 Source A related resource from which the described resource is derived Thrombosis research https://www.socictopen.socict.org/files/original/0c6d7752c439cadcd301dc992fba605d.pdf 021a56330359222f677fee8364bf3a93 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Anti–SARS-CoV Immunoglobulin G in Healthcare Workers, Guangzhou, China Creator An entity primarily responsible for making the resource Wei-Qing Chen, Ciyong Lu, Tze-wai Wong, Wen-Hua Ling, Zhong-Ning Lin, Yuantao Hao, Qing Liu, Ji-Qian Fang, Yun He, Futian Luo, Jin Jing, Li Ling, Xiang Ma, Yimin Liu, Guihua Chen, Jian Huang, Yuan-Sen Jiang, Wen-Qi Jiang, Hequn Zou, Guang-Mei Yan Description An account of the resource To determine the prevalence of inapparent infection with severe acute respiratory syndrome (SARS) among healthcare workers, we performed a serosurvey to test for immunoglobulin (Ig) G antibodies to the SARS coronavirus (SARS-CoV) among 1,147 healthcare workers in 3 hospitals that admitted SARS patients in mid-May 2003. Among them were 90 healthcare workers with SARS. As a reference group, 709 healthcare workers who worked in 2 hospitals that never admitted any SARS patients were similarly tested. The seroprevalence rate was 88.9% (80/90) for healthcare workers with SARS and 1.4% (15/1,057) for healthcare workers who were apparently healthy. The seroprevalence in the reference group was 0.4% (3/709). These findings suggest that inapparent infection is uncommon. Low level of immunity among unaffected healthcare workers reinforces the need for adequate personal protection and other infection control measures in hospitals to prevent future epidemics. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Subject The topic of the resource SARS, seroprevalence, healthcare workers, China, research Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1101.040138 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/7c89e0031a2316d04ef26c81bceb354a.pdf 5d478a7a1c4402cd25d44528770204aa Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibodies against MERS Coronavirus in Dromedary Camels, Kenya, 1992–2013 Creator An entity primarily responsible for making the resource Victor M. Corman, Joerg Jores, Benjamin Meyer, Mario Younan, Anne M. Liljander, Mohammed Y. Said, Ilona Gluecks, Erik Lattwein, Berend-Jan Bosch, Jan Felix Drexler, Set Bornstein, Christian Drosten, Marcel A. Müller Description An account of the resource Dromedary camels are a putative source for human infections with Middle East respiratory syndrome coronavirus. We showed that camels sampled in different regions in Kenya during 1992–2013 have antibodies against this virus. High densities of camel populations correlated with increased seropositivity and might be a factor in predicting long-term virus maintenance. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Middle East respiratory syndrome coronavirus, MERS-CoV, Viruses, coronavirus, Dromedary camels, reservoir Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid2008.140596 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/5a332728d1673d3841572a639509b908.pdf fe00d9a28297367b2a9fefe147c73a8c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibodies against MERS Coronavirus in Dromedary Camels, United Arab Emirates, 2003 and 2013 Creator An entity primarily responsible for making the resource Chantal B. E. M. Reusken, Gert-Jan Godeke, Marion P. G. Koopmans, Christian Drosten, Janko van Beek, Marcel A. Müller, Erik Lattwein, Ulrich Wernery, Renate Wernery, Benjamin Meyer, Berend-Jan Bosch, Victor M. Corman, Jan F. Drexler, Doreen Muth, Daniel Ritz, Stephan Kallies, Artem Siemens Description An account of the resource Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute respiratory tract infection in humans in the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary camel serum samples from the United Arab Emirates; 151 of 651 samples were obtained in 2003, well before onset of the current epidemic, and 500 serum samples were obtained in 2013. Recombinant spike protein–specific immunofluorescence and virus neutralization tests enabled clear discrimination between MERS-CoV and bovine CoV infections. Most (632/651, 97.1%) camels had antibodies against MERS-CoV. This result included all 151 serum samples obtained in 2003. Most (389/651, 59.8%) serum samples had MERS-CoV–neutralizing antibody titers >1,280. Dromedary camels from the United Arab Emirates were infected at high rates with MERS-CoV or a closely related, probably conspecific, virus long before the first human MERS cases. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource Viruses, coronavirus, MERS-CoV, Middle East respiratory syndrome, MERS, Middle East respiratory syndrome coronavirus Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid2004.131746 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine https://www.socictopen.socict.org/files/original/b3b1bb7d858c7a1ddffd9a18546ead19.pdf a248997e5bd1e558c4c862c79cd98d2f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibodies to SARS-Coronavirus in Civets Creator An entity primarily responsible for making the resource Yan-wei Sun, Xianzhu Xia, Meng Yu, Shengwang Liu, Hua Xiang, Jinding Chen, Gary Crameri, Lin-Fa Wang, Xiangang Kong, Changchun Tu, Yunwen Hu, Bryan T. Eaton, Hua Xuan, Yedong Yu Description An account of the resource Using three different assays, we examined 103 serum samples collected from different civet farms and a market in China in June 2003 and January 2004. While civets on farms were largely free from SARS-CoV infection, ≈80% of the animals from one animal market in Guangzhou contained significant levels of antibody to SARS-CoV, which suggests no widespread infection among civets resident on farms, and the infection of civets in the market might be associated with trading activities under the conditions of overcrowding and mixing of various animal species. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource China, Antibodies, dispatch, SARS-CoV, civets Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1012.040520 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine https://www.socictopen.socict.org/files/original/b7a8e6bc6d880f6304d9c25d06de9feb.pdf 1bb8217b096d4ece7f06cca97c925e52 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibodies, epicenter of SARS-CoV-2 immunology. Creator An entity primarily responsible for making the resource Simone Pecetta, Mariagrazia Pizza, Claudia Sala, Emanuele Andreano, Piero Pileri, Marco Troisi, Elisa Pantano, Noemi Manganaro, Rino Rappuoli Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1038/s41418-020-00711-w Source A related resource from which the described resource is derived Cell death and differentiation https://www.socictopen.socict.org/files/original/5126ca13de2bc411230ceca0b8b6016f.pdf fad2291f574cebb3ca78b69cf856dbc5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS Creator An entity primarily responsible for making the resource Walter Fierz, Brigitte Walz Description An account of the resource Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical signs of infections in children, second, the early appearance of IgG in certain patients. From the point of view of immune system physiology, such an early rise of specific IgG is expected in secondary immune responses when memory to a cross-reactive antigen is present, usually from an earlier infection with a coronavirus. It is actually typical for the immune system to respond, to what it already knows, a phenomenon that has been observed in many infections with closely related viruses and has been termed “original antigenic sin.” The question then arises whether such cross-reactive antibodies are protective or not against the new virus. The worst scenario would be when such cross-reactive memory antibodies to related coronaviruses would not only be non-protective but even enhance infection and the clinical course. Such a phenomenon of antibody dependent enhancement (ADE) has already been described in several viral infections. Thus, the development of IgG against SARS-CoV-2 in the course of COVID-19 might not be a simple sign of viral clearance and developing protection against the virus. On the contrary, due to cross-reaction to related coronavirus strains from earlier infections, in certain patients IgG might enhance clinical progression due to ADE. The patient's viral history of coronavirus infection might be crucial to the development of the current infection with SARS-CoV-2. Furthermore, it poses a note of caution when treating COVID-19 patients with convalescent sera. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource cross-reactivity, antibody-dependent enhancement (ADE), Receptor binding protein, COVID-19, antigenic sin, protecting IgG Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2020.01120 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/cdde8f0b2295438da6a71a2c6e4193f1.pdf e39f82268310475b39a785a8af8b5e94 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibody Engineering Towards Enhancement of Spike Protein SARS-COV-2 -m396 Binding Affinity Creator An entity primarily responsible for making the resource Fateme Sefid, Zahra Payandeh, Ghasem Azamirad, Iraj Rasooli Description An account of the resource Introduction: The SARS-COV-2 is a non-segmented positive-sense RNA virus that belongs to the genus Beta Coronavirus. The envelope-anchored trimeric spike protein on the virus surface is considered to be the key protein for the viral entry into the host cells. The angiotensin-converting enzyme 2 (ACE2) is reported to be the effective human receptor for SARS-COV-2.  ACE2 receptor can be prevented by neutralizing antibodies such as m396 targeting the virus receptor-binding site. Material and Methods: Considering the importance of computational docking, and in silico affinity maturation we aimed at finding the important amino acids of the m396 antibody. These amino acids were then replaced by other amino acids to improve antibody-binding affinity to receptor-binding domain (RBD) of the SARS-COV-2 spike protein. Finally, we measured the binding affinity of antibody variants to the antigen. Result: Our findings disclosed that several variant mutations could successfully improve the characteristics of the antibody binding compared to the normal antibodies. Conclusion: the antibodies developed may be possible candidates for stronger affinity binding to antigens. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource coronavirus, Bioinformatics, SARS-CoV-2, affinity maturation Identifier An unambiguous reference to the resource within a given context 10.22037/rrr.v5i.32838 Source A related resource from which the described resource is derived Regeneration, Reconstruction & Restoration Publisher An entity responsible for making the resource available Shahid Beheshti University of Medical Sciences Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medicine (General) https://www.socictopen.socict.org/files/original/63109bc18239f7e66d786a4cff19de04.pdf 9c715884f572f2db1862387ea94a4d69 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibody Response and Disease Severity in Healthcare Worker MERS Survivors Creator An entity primarily responsible for making the resource Abeer N. Alshukairi, Imran Khalid, Waleed A. Ahmed, Ashraf M. Dada, Daniyah T. Bayumi, Laut S. Malic, Sahar Al Thawadi, Kim Ignacio, Hanadi S. Alsalmi, Hail M. Al-Abdely, Ghassan Y. Wali, Ismael A. Qushmaq, Basem M. Alraddadi, Stanley Perlman Description An account of the resource We studied antibody response in 9 healthcare workers in Jeddah, Saudi Arabia, who survived Middle East respiratory syndrome, by using serial ELISA and indirect immunofluorescence assay testing. Among patients who had experienced severe pneumonia, antibody was detected for >18 months after infection. Antibody longevity was more variable in patients who had experienced milder disease. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Antibody, Middle East respiratory syndrome coronavirus, MERS-CoV, ELISA, Indirect immunofluorescence assay, IFA Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid2206.160010 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/88ff5b05b0500274414b131ecf190db6.pdf 96371277f03a72f428be703f6c993bc1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antibody response and protection of inactivated-local isolate vaccine for infectious bronchitis in laying chicken Creator An entity primarily responsible for making the resource Risa Indriani, Darminto Description An account of the resource Infectious bronchitis (IB) is an acute highly contagious viral respiratory disease of poultry caused by Coronavirus. IBV infection consists of many serotypes and can only be controlled by vaccination. An effective IB vaccine should be prepared from local isolates, due to the antigenic variation among serotypes. The aims of this research were to develop inactivated IB vaccine derived from IBV local isolate and to determine the efficacy of that vaccine in layer flocks. Five layer chicken groups were used in this experiments, group I was vaccinated with commercial IBV live vaccine thrice, group II was vaccinated with commercial IBV live vaccine once and repeated with inactivated local IBV isolate twice, group III was vaccinated with commercial IBV live vaccine once and repeated with commercial inactivated twice, group IV was vaccinated with IBV live vaccine once, and group V was not vaccinated. After the chickens reached at a stable egg production they were challenged with IBV local isolates. Antibody responses were examined by means of haemagglutination hibitition (HI) test and HI titres were expressed as log2 of the reciprocal of the highest dilution of serum causing inhibition of a log2 HA titre of 2. The mean titres of antibody responses of chicken in group I, II, III, IV, and V was 4.9 ± 0.87, 6.8 ± 0.97, 7.7 ± 0.46, 2.9 ± 0.94, and 2.0 ± 1.67 respectively. The levels of protection against challenges were determined by viral isolation, this in group I, II, III, IV, and V was 63, 73, 60, 50, and 0% respectively. Clinical symptom of egg quality was slightly reduced in group I, IV, and V and it were unchanged in group II and III. Group II gave better in number of egg production than the other groups. The results indicated that the IBV inactivated localisolate vaccine gave high titres of antibody and higher protection rates than that of commercial IBV inactivated vaccine. Inaddition, IBV local isolate vaccinated group prevented from declining egg production after challenged with IBV local isolate. Date A point or period of time associated with an event in the lifecycle of the resource 2001 Subject The topic of the resource vaccine, Infectious Bronchitis, Layer, antibody titre, challenge virus Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Jurnal Ilmu Ternak dan Veteriner Publisher An entity responsible for making the resource available Pusat Penelitian dan Pengembangan Peternakan Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture, Animal culture