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Development of a protocol for the auto-generation of explicit aqueous-phase oxidation schemes of organic compounds
This paper presents a new CAPRAM–GECKO-A protocol for mechanism auto-generation of aqueous-phase organic processes. For the development, kinetic data in the literature were reviewed and a database with 464 aqueous-phase reactions of the hydroxyl…
Position: 8013 (28 views)
Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus.
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe acute respiratory failure and considerable extrapumonary organ dysfuction with substantial high mortality. For the limited number of autopsy reports, small animal models are…
Position: 15143 (20 views)
From the Beginning Until Today: Current Status of SARS
Position: 6325 (31 views)
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.
New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a…
Position: 17839 (17 views)
Reconstruction of family-level phylogenetic relationships within Demospongiae (Porifera) using nuclear encoded housekeeping genes.
Demosponges are challenging for phylogenetic systematics because of their plastic and relatively simple morphologies and many deep divergences between major clades. To improve understanding of the phylogenetic relationships within Demospongiae, we…
Position: 12074 (23 views)
Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses.
The severity of respiratory viral infections is partially determined by the cellular response mounted by infected lung epithelial cells. Disease prevention and treatment is dependent on our understanding of the shared and unique responses elicited by…
Position: 14073 (21 views)
Short (16-mer) locked nucleic acid splice-switching oligonucleotides restore dystrophin production in Duchenne Muscular Dystrophy myotubes.
Splice-switching antisense oligonucleotides (SSOs) offer great potential for RNA-targeting therapies, and two SSO drugs have been recently approved for treating Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA). Despite promising…
Position: 15143 (20 views)
Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis.
Patients with neurodegenerative diseases such as multiple sclerosis, Parkinson's, and Alzheimer's often present with lower urinary tract symptoms (LUTS, urinary frequency, urgency, nocturia and retention) resulting from damage to the peripheral and…
Position: 10231 (25 views)
Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong.
The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak…
Position: 4045 (38 views)
An evaluation of emergency guidelines issued by the World Health Organization in response to four infectious disease outbreaks.
BACKGROUND:The production of high-quality guidelines in response to public health emergencies poses challenges for the World Health Organization (WHO). The urgent need for guidance and the paucity of structured scientific data on emerging diseases…
Position: 3634 (40 views)