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Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a…
Position: 10217 (25 views)
The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase.
DNA ligases are essential both to in vivo replication, repair and recombination processes, and in vitro molecular biology protocols. Prior characterization of DNA ligases through gel shift assays has shown the presence of a nick site to be essential…
Position: 9431 (26 views)
Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.
To determine if immune phenotypes associated with immunosenescence predict risk of respiratory viral infection in elderly nursing home residents.Residents ≥ 65 years from 32 nursing homes in 4 Canadian cities were enrolled in Fall 2009, 2010 and…
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The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters.
In 2012 a novel coronavirus, MERS-CoV, associated with severe respiratory disease emerged in the Arabian Peninsula. To date, 55 human cases have been reported, including 31 fatal cases. Several of the cases were likely a result of human-to-human…
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Mating of the stichotrichous ciliate Oxytricha trifallax induces production of a class of 27 nt small RNAs derived from the parental macronucleus.
Ciliated protozoans possess two types of nuclei; a transcriptionally silent micronucleus, which serves as the germ line nucleus, and a transcriptionally active macronucleus, which serves as the somatic nucleus. The macronucleus is derived from a new…
Position: 11129 (24 views)
Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model.
In terms of its highly pathogenic nature, there remains a significant need to further define the immune pathology of SARS-coronavirus (SARS-CoV) infection, as well as identify correlates of immunity to help develop vaccines for severe coronaviral…
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Urgent Call for Research on Middle East Respiratory Syndrome (MERS) in Korea
Position: 6312 (31 views)
Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection.
Coronaviruses cause respiratory disease in humans that can range from mild to severe. However, the pathogenesis of pulmonary coronavirus infections is poorly understood. Mouse hepatitis virus type 1 (MHV-1) is a group 2 coronavirus capable of causing…
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Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.
While human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes preferentially target specific regions of the viral proteome, HIV-1 features that contribute to immune recognition are not well understood. One hypothesis is that…
Position: 9431 (26 views)
Investigation on some qualitative and quantitative characteristics of oriental beech in the optimal phase (Case study: Sangdeh, Caspian forests of Iran)
In order to investigate some of the qualitative and quantitative characteristics of oriental beech (Fagus orientalis Lipsky) at optimal phase, this research was carried out in the Caspian forests of Iran in 1999. The study area consisted of a natural…
Position: 10217 (25 views)