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Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial
Abstract Background It had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical trials. Results from in…
Position: 4273 (37 views)
Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
Dick AW Janssen,1 Frank MJ Martens,1 Liesbeth L de Wall,1 Hendrikje MK van Breda,2 John PFA Heesakkers1 1Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, 2Department of Urology, University Medical Center Utrecht, Utrecht,…
Position: 2420 (47 views)
Functional and Genetic Analysis of Coronavirus Replicase-Transcriptase Proteins.
The coronavirus replicase-transcriptase complex is an assembly of viral and cellular proteins that mediate the synthesis of genome and subgenome-sized mRNAs in the virus-infected cell. Here, we report a genetic and functional analysis of 19…
Position: 752 (66 views)
An update for cladoceran fauna (Crustacea, Branchiopoda) from Lake Paranoá, Central Brazil, with the first description of a male of Leydigiopsis ornata Daday, 1905
Abstract Until recently, Lake Paranoá was considered the most thoroughly studied aquatic environment in relation to cladocerans in the Federal District. However, in new samplings carried out during the dry and rainy seasons of 2014, we found 10 new…
Position: 2420 (47 views)
Finger Tapping Clinimetric Score Prediction in Parkinson's Disease Using Low-Cost Accelerometers
The motor clinical hallmarks of Parkinson's disease (PD) are usually quantified by physicians using validated clinimetric scales such as the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). However, clinical ratings are prone to subjectivity and…
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Correction to: Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy
Correction After Publication of the article [1], it has been brought to our attention that an author’s name has been spelt incorrectly. The correct spelling should be “Massimo Ciccozzi”, but it was previously included as “Massimo Cicozzi”. The…
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Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus
Abstract Background Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the…
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A novel electrophototrophic bacterium Rhodopseudomonas palustris strain RP2, exhibits hydrocarbonoclastic potential in anaerobic environments
An electrophototrophic, hydrocarbonoclastic bacterium Rhodopseudomonas palustris stain RP2 was isolated from the anodic biofilms of hydrocarbon fed microbial electrochemical remediation systems (MERS). Salient properties of the strain RP2 were direct…
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Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced…
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Synthesis and solvodynamic diameter measurements of closely related mannodendrimers for the study of multivalent carbohydrate–protein interactions
This paper describes the synthesis of three closely related families of mannopyranoside-containing dendrimers for the purpose of studying subtle structural parameters involved in the measurements of multivalent carbohydrate–protein binding…
Position: 5866 (32 views)