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Identification and Characterization of Three Novel Small Interference RNAs That Effectively Down-Regulate the Isolated Nucleocapsid Gene Expression of SARS Coronavirus
Nucleocapsid (N) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a major pathological determinant in the host that may cause host cell apoptosis, upregulate the proinflammatory cytokine production, and block innate…
Position: 10259 (25 views)
The Non-Hemostatic Aspects of Transfused Platelets
Platelets transfusion is a safe process, but during or after the process, the recipient may experience an adverse reaction and occasionally a serious adverse reaction (SAR). In this review, we focus on the inflammatory potential of platelet…
Position: 9466 (26 views)
Graveoline Analogs Exhibiting Selective Acetylcholinesterase Inhibitory Activity as Potential Lead Compounds for the Treatment of Alzheimer’s Disease
This study designed and synthesized a series of new graveoline analogs on the basis of the structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. The activity of these analogs was also evaluated. Results showed that the…
Position: 7391 (29 views)
Identification of Cis-Acting Elements on Positive-Strand Subgenomic mRNA Required for the Synthesis of Negative-Strand Counterpart in Bovine Coronavirus
It has been demonstrated that, in addition to genomic RNA, sgmRNA is able to serve as a template for the synthesis of the negative-strand [(−)-strand] complement. However, the cis-acting elements on the positive-strand [(+)-strand] sgmRNA required…
Position: 5206 (34 views)
Short-term variability of copepod abundance in Jurumirim Reservoir, São Paulo, Brazil
Short-term variability in composition and abundance of copepod populations were studied during the dry (winter) and rainy (summer) seasons, at the dam region of Jurumirim Reservoir, São Paulo, Brazil. An intensive sampling program was carried out…
Position: 12099 (23 views)
Prevalence of diabetes in the 2009 influenza A (H1N1) and the Middle East respiratory syndrome coronavirus: a systematic review and meta-analysis
Over the past two decades a number of severe acute respiratory infection outbreaks such as the 2009 influenza A (H1N1) and the Middle East respiratory syndrome coronavirus (MERS-CoV) have emerged and presented a considerable global public health…
Position: 8735 (27 views)
Adaptation as an Integrated System of Clinical-Anamnestic, Immunological and Psychological Components in Children Raised in Orphanages
The aim of the study was to investigate the characteristics of adaptation of orphanages on the basis of the findings of a comprehensive study of the components of this phenomenon and develop a mathematical model of evaluation of the current state of…
Position: 11171 (24 views)
Genomic Analysis of 15 Human Coronaviruses OC43 (HCoV-OC43s) Circulating in France from 2001 to 2013 Reveals a High Intra-Specific Diversity with New Recombinant Genotypes
Human coronavirus OC43 (HCoV-OC43) is one of five currently circulating human coronaviruses responsible for respiratory infections. Like all coronaviruses, it is characterized by its genome’s high plasticity. The objectives of the current study were…
Position: 14097 (21 views)
Detection of Coronaviruses in Bats of Various Species in Italy
Bats are natural reservoirs for many mammalian coronaviruses, which have received renewed interest after the discovery of the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) CoV in humans. This study describes…
Position: 9466 (26 views)
Immunology of Bats and Their Viruses: Challenges and Opportunities
Bats are reservoir hosts of several high-impact viruses that cause significant human diseases, including Nipah virus, Marburg virus and rabies virus. They also harbor many other viruses that are thought to have caused disease in humans after…
Position: 11171 (24 views)