Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance.

Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance.

Carleen Klumpp-Thomas, Heather Kalish, Jennifer Hicks, Jennifer Mehalko, Matthew Drew, Matthew J Memoli, Matthew D Hall, Dominic Esposito, Kaitlyn Sadtler

Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics.

2021

coronavirus, spike protein, covid-19, Pandemic, SARS-CoV-2, D614G

10.1093/infdis/jiaa743

The Journal of infectious diseases