A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
Título
A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation
Autor
Guan-Min Jiang, Xiaoxue Chen, Sisi Kang, Mei Yang, Suhua He, Yueming Wang, Yao-Qing Chen, Zhongsi Hong, Jing Liu, Qiuyue Chen, Ziliang Zhou, Zhechong Zhou, Zhaoxia Huang, Xi Huang, Huanhuan He, Weihong Zheng, Hua-Xin Liao, Fei Xiao, Hong Shan, Shoudeng Chen
Descripción
While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.
Fecha
2021
Identificador
10.1038/s41467-021-23036-9
Fuente
Epidemiology and Health
Editor
Korean Society of Epidemiology
Cobertura
Science
Archivos
Colección
Citación
Guan-Min Jiang, Xiaoxue Chen, Sisi Kang, Mei Yang, Suhua He, Yueming Wang, Yao-Qing Chen, Zhongsi Hong, Jing Liu, Qiuyue Chen, Ziliang Zhou, Zhechong Zhou, Zhaoxia Huang, Xi Huang, Huanhuan He, Weihong Zheng, Hua-Xin Liao, Fei Xiao, Hong Shan, Shoudeng Chen, “A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation,” SOCICT Open, consulta 18 de abril de 2026, https://www.socictopen.socict.org/items/show/9202.
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